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Target
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Ligand
BDBM50123850
Substrate
n/a
Meas. Tech.
ChEMBL_1519474 (CHEMBL3625533)
IC50
1420±n/a nM
Citation
 Kim, YG; Seo, JH; Kwak, JH; Shin, KJ Discovery of a potent enoyl-acyl carrier protein reductase (FabI) inhibitor suitable for antistaphylococcal agent. Bioorg Med Chem Lett 25:4481-6 (2015) [PubMed]  Article
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Synonyms:
Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | FABI_STAAR | NADPH-dependent enoyl-ACP reductase | fabI | trans-2-enoyl-[acyl carrier protein] reductase
Type:
Enzyme
Mol. Mass.:
27989.00
Organism:
Staphylococcus aureus
Description:
Q6GI75
Residue:
256
Sequence:
MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK
  
Inhibitor
Name:
BDBM50123850
Synonyms:
CHEMBL3623420
Type:
Small organic molecule
Emp. Form.:
C25H19Cl2NO3
Mol. Mass.:
452.329
SMILES:
Clc1ccc(Oc2cn(Cc3ccccc3)c(COc3ccccc3)cc2=O)c(Cl)c1
Structure:
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