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Target
Reverse transcriptase
Ligand
BDBM93122
Substrate
n/a
Meas. Tech.
ChEMBL_1548831 (CHEMBL3755387)
IC50
3410±n/a nM
Citation
 Bastos, MM; Costa, CC; Bezerra, TC; da Silva, Fde C; Boechat, N Efavirenz a nonnucleoside reverse transcriptase inhibitor of first-generation: Approaches based on its medicinal chemistry. Eur J Med Chem 108:455-65 (2016) [PubMed]  Article
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM93122
Synonyms:
3-Hydroxy-2-oxo-3-trifluoromethylindole, 25
Type:
Small molecule
Emp. Form.:
C11H7ClF3NO3
Mol. Mass.:
293.626
SMILES:
CC(=O)N1C(=O)C(O)(c2cc(Cl)ccc12)C(F)(F)F
Structure:
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