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Target
Reverse transcriptase
Ligand
BDBM50137116
Substrate
n/a
Meas. Tech.
ChEMBL_1548831 (CHEMBL3755387)
IC50
2.0±n/a nM
Citation
 Bastos, MM; Costa, CC; Bezerra, TC; da Silva, Fde C; Boechat, N Efavirenz a nonnucleoside reverse transcriptase inhibitor of first-generation: Approaches based on its medicinal chemistry. Eur J Med Chem 108:455-65 (2016) [PubMed]  Article
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50137116
Synonyms:
CHEMBL378856
Type:
Small organic molecule
Emp. Form.:
C15H20N2O4S
Mol. Mass.:
324.395
SMILES:
COc1ccc2NC(=O)[C@H](CSC)N(C(=O)OC(C)C)c2c1
Structure:
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