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Target
Polyunsaturated fatty acid lipoxygenase ALOX15
Ligand
BDBM59267
Substrate
n/a
Meas. Tech.
ChEMBL_1556331 (CHEMBL3766390)
IC50
>50000±n/a nM
Citation
 Armstrong, MM; Freedman, CJ; Jung, JE; Zheng, Y; Kalyanaraman, C; Jacobson, MP; Simeonov, A; Maloney, DJ; van Leyen, K; Jadhav, A; Holman, TR A potent and selective inhibitor targeting human and murine 12/15-LOX. Bioorg Med Chem 24:1183-90 (2016) [PubMed]  Article
Target
Name:
Polyunsaturated fatty acid lipoxygenase ALOX15
Synonyms:
15-Lipoxygenase-1 (15-LOX-1) | ALOX15 | Arachidonate 15-lipoxygenase | Arachidonate 15-lipoxygenase-1 | LOG15 | LOX15_HUMAN | Reticulocyte 15-lipoxygenase-1 | Sphingosine 1-phosphate receptor 1 (S1P1)
Type:
Protein
Mol. Mass.:
74804.05
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
662
Sequence:
MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMSTGGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVSLHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQHASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQPVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSVAI
  
Inhibitor
Name:
BDBM59267
Synonyms:
(5E)-5-(3-methyl-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)-N-(phenylmethyl)-1,2-dihydropyrazole-3-carboxamide | (5E)-5-(3-methyl-6-oxo-1-cyclohexa-2,4-dienylidene)-N-(phenylmethyl)-1,2-dihydropyrazole-3-carboxamide | (5E)-N-benzyl-5-(3-methyl-6-oxocyclohexa-2,4-dien-1-ylidene)-1,2-dihydropyrazole-3-carboxamide | (5E)-N-benzyl-5-(6-keto-3-methyl-cyclohexa-2,4-dien-1-ylidene)-3-pyrazoline-3-carboxamide | 5-(2-Hydroxy-5-methyl-phenyl)-2H-pyrazole-3-carboxylic acid benzylamide | MLS000551826 | SMR000145751 | cid_6097793
Type:
Small organic molecule
Emp. Form.:
C18H17N3O2
Mol. Mass.:
307.3465
SMILES:
Cc1ccc(O)c(c1)-c1cc([nH]n1)C(=O)NCc1ccccc1
Structure:
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