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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50149942
Substrate
n/a
Meas. Tech.
ChEMBL_1558446 (CHEMBL3773322)
IC50
11±n/a nM
Citation
 Zhang, H; Tong, R; Bai, L; Shi, J; Ouyang, L Emerging targets and new small molecule therapies in Parkinson's disease treatment. Bioorg Med Chem 24:1419-30 (2016) [PubMed]  Article
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50149942
Synonyms:
CHEMBL3770663
Type:
Small organic molecule
Emp. Form.:
C19H25NO
Mol. Mass.:
283.4079
SMILES:
CNC[C@@]1(CC[C@@](C)(O)CC1)c1ccc2ccccc2c1 |r,wU:6.7,wD:3.2,(-7.77,.92,;-6.7,1.54,;-5.36,.77,;-4.02,1.54,;-5.36,2.27,;-5.36,3.81,;-4.03,4.58,;-5.11,5.17,;-2.95,5.18,;-2.69,3.81,;-2.69,2.27,;-2.69,.77,;-2.69,-.77,;-1.33,-1.54,;,-.77,;1.33,-1.54,;2.67,-.77,;2.67,.77,;1.33,1.54,;,.77,;-1.33,1.54,)|
Structure:
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