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Target
Phospholipase A2, membrane associated
Ligand
BDBM50149981
Substrate
n/a
Meas. Tech.
ChEMBL_1558489 (CHEMBL3773524)
IC50
143±n/a nM
Citation
 Vasilakaki, S; Barbayianni, E; Leonis, G; Papadopoulos, MG; Mavromoustakos, T; Gelb, MH; Kokotos, G Development of a potent 2-oxoamide inhibitor of secreted phospholipase A2 guided by molecular docking calculations and molecular dynamics simulations. Bioorg Med Chem 24:1683-95 (2016) [PubMed]  Article
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:
Hydrolase
Mol. Mass.:
16101.20
Organism:
Homo sapiens (Human)
Description:
The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:
144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
  
Inhibitor
Name:
BDBM50149981
Synonyms:
CHEMBL3769794
Type:
Small organic molecule
Emp. Form.:
C21H39NO4
Mol. Mass.:
369.5387
SMILES:
CCCCCCCCCCCCCCC(=O)C(=O)N[C@@H](C(C)C)C(O)=O |r|
Structure:
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