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Target
Histone deacetylase 3
Ligand
BDBM50151281
Substrate
n/a
Meas. Tech.
ChEMBL_1559109 (CHEMBL3774116)
IC50
21±n/a nM
Citation
 Gong, CJ; Gao, AH; Zhang, YM; Su, MB; Chen, F; Sheng, L; Zhou, YB; Li, JY; Li, J; Nan, FJ Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy. Eur J Med Chem 112:81-90 (2016) [PubMed]  Article
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM50151281
Synonyms:
CHEMBL3770504
Type:
Small organic molecule
Emp. Form.:
C20H22F3N3O2S2
Mol. Mass.:
457.533
SMILES:
FC(F)(F)C(=O)CCCCNC(=O)c1nc(sc1C1CC1)-c1nc2CCCCc2s1
Structure:
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