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Target
Aurora kinase B
Ligand
BDBM50154291
Substrate
n/a
Meas. Tech.
ChEMBL_1560695 (CHEMBL3778046)
IC50
<5000±n/a nM
Citation
 Shchekotikhin, AE; Dezhenkova, LG; Tsvetkov, VB; Luzikov, YN; Volodina, YL; Tatarskiy, VV; Kalinina, AA; Treshalin, MI; Treshalina, HM; Romanenko, VI; Kaluzhny, DN; Kubbutat, M; Schols, D; Pommier, Y; Shtil, AA; Preobrazhenskaya, MN Discovery of antitumor anthra[2,3-b]furan-3-carboxamides: Optimization of synthesis and evaluation of antitumor properties. Eur J Med Chem 112:114-29 (2016) [PubMed]  Article
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50154291
Synonyms:
CHEMBL3775181
Type:
Small organic molecule
Emp. Form.:
C23H22N2O9S
Mol. Mass.:
502.494
SMILES:
CS(O)(=O)=O.Cc1oc2c(O)c3C(=O)c4ccccc4C(=O)c3c(O)c2c1C(=O)N1CC[C@H](N)C1 |r|
Structure:
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