Reaction Details  Report a problem with these data
Target
Cyclin-dependent kinase 4
Ligand
BDBM50347389
Substrate
n/a
Meas. Tech.
ChEMBL_1561546 (CHEMBL3776183)
IC50
44700±n/a nM
Citation
 Vymetalová, L; Havlícek, L; ?turc, A; Skrá?ková, Z; Jorda, R; Pospí?il, T; Strnad, M; Kry?tof, V 5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases. Eur J Med Chem 110:291-301 (2016) [PubMed]  Article
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM50347389
Synonyms:
CHEMBL1801932
Type:
Small organic molecule
Emp. Form.:
C22H32N6
Mol. Mass.:
380.5297
SMILES:
CC(C)c1cnn2c(NCc3ccccc3)cc(NCCCCCCN)nc12
Structure:
Search PDB for entries with ligand similarity: