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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM50005209
Substrate
n/a
Meas. Tech.
ChEMBL_1570462 (CHEMBL3794689)
Ki
<3±n/a nM
Citation
 Nishiguchi, GA; Burger, MT; Han, W; Lan, J; Atallah, G; Tamez, V; Lindvall, M; Bellamacina, C; Garcia, P; Feucht, P; Zavorotinskaya, T; Dai, Y; Wong, K Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold. Bioorg Med Chem Lett 26:2328-32 (2016) [PubMed]  Article
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM50005209
Synonyms:
CHEMBL3103867
Type:
Small organic molecule
Emp. Form.:
C22H23FN6O
Mol. Mass.:
406.456
SMILES:
N[C@H]1CCCN(C1)c1ccncc1NC(=O)c1nc(ccc1N)-c1ccccc1F |r|
Structure:
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