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Target
Protein arginine N-methyltransferase 1 [11-371]
Ligand
BDBM50158095
Substrate
n/a
Meas. Tech.
ChEBML_1564207
IC50
39000±n/a nM
Citation
 Ferreira de Freitas, R; Eram, MS; Szewczyk, MM; Steuber, H; Smil, D; Wu, H; Li, F; Senisterra, G; Dong, A; Brown, PJ; Hitchcock, M; Moosmayer, D; Stegmann, CM; Egner, U; Arrowsmith, C; Barsyte-Lovejoy, D; Vedadi, M; Schapira, M Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor. J Med Chem 59:1176-83 (2016) [PubMed]  Article
Target
Name:
Protein arginine N-methyltransferase 1 [11-371]
Synonyms:
ANM1_HUMAN | HMT2 | HRMT1L2 | IR1B4 | PRMT1 | Protein arginine N-methyltransferase 1 (PRMT1) | Protein arginine methyltransferase 1 (PRMT1) | Protein-arginine N-methyltransferase 1
Type:
Protein
Mol. Mass.:
41506.52
Organism:
Homo sapiens (Human)
Description:
Q99873[11-371]
Residue:
361
Sequence:
MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM50158095
Synonyms:
CHEMBL3780444
Type:
Small organic molecule
Emp. Form.:
C5H14N2
Mol. Mass.:
102.1781
SMILES:
CNCCN(C)C
Structure:
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