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Target
Low molecular weight phosphotyrosine protein phosphatase
Ligand
BDBM50158368
Substrate
n/a
Meas. Tech.
ChEMBL_1566147 (CHEMBL3787816)
IC50
62500±n/a nM
Citation
 Cerón-Romero, L; Paoli, P; Camici, G; Flores-Morales, V; Rios, MY; Ramírez-Espinosa, JJ; Hidalgo-Figueroa, S; Navarrete-Vázquez, G; Estrada-Soto, S In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives. Bioorg Med Chem Lett 26:2018-22 (2016) [PubMed]  Article
Target
Name:
Low molecular weight phosphotyrosine protein phosphatase
Synonyms:
3.1.3.2 | 3.1.3.48 | ACP1 | Adipocyte acid phosphatase | LMW-PTP | LMW-PTPase | LMWPTP | Low molecular weight cytosolic acid phosphatase | PPAC_HUMAN | Red cell acid phosphatase 1 | low molecular weight phosphotyrosine protein phosphatase isoform c
Type:
n/a
Mol. Mass.:
18042.81
Organism:
Homo sapiens (Human)
Description:
P24666
Residue:
158
Sequence:
MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
  
Inhibitor
Name:
BDBM50158368
Synonyms:
CHEMBL3787288
Type:
Small organic molecule
Emp. Form.:
C31H48O3
Mol. Mass.:
468.711
SMILES:
[H][C@]12CC[C@]3([H])[C@@]4(C)CCC(=O)C(C)(C)[C@]4([H])CC[C@@]3(C)[C@]1(C)CC[C@]1(CCC(C)(C)C=C21)C(=O)OC |r,t:34|
Structure:
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