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Target
Prostaglandin E2 receptor EP2 subtype
Ligand
BDBM50169613
Substrate
n/a
Meas. Tech.
ChEMBL_1578429 (CHEMBL3808246)
EC50
11±n/a nM
Citation
 Ogawa, S; Watanabe, T; Sugimoto, I; Moriyuki, K; Goto, Y; Yamane, S; Watanabe, A; Tsuboi, K; Kinoshita, A; Kigoshi, H; Tani, K; Maruyama, T Discovery of G Protein-Biased EP2 Receptor Agonists. ACS Med Chem Lett 7:306-11 (2016) [PubMed]  Article
Target
Name:
Prostaglandin E2 receptor EP2 subtype
Synonyms:
PE2R2_HUMAN | PGE receptor EP2 subtype | PTGER2 | Prostaglandin E2 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP4 subtype | Prostanoid EP2 Receptor
Type:
Enzyme
Mol. Mass.:
39775.71
Organism:
Homo sapiens (Human)
Description:
P43116
Residue:
358
Sequence:
MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
  
Inhibitor
Name:
BDBM50169613
Synonyms:
CHEMBL3806284
Type:
Small organic molecule
Emp. Form.:
C20H20F3NO5S
Mol. Mass.:
443.437
SMILES:
[H][C@]12C[C@@H](O)[C@H](COc3ccccc3C(F)(F)F)[C@@]1([H])CC[C@@H](O2)c1nc(cs1)C(O)=O |r|
Structure:
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