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Target
Histone deacetylase 1
Ligand
BDBM50175039
Substrate
n/a
Meas. Tech.
ChEBML_1580268
IC50
200±n/a nM
Citation
 Ontoria, JM; Paonessa, G; Ponzi, S; Ferrigno, F; Nizi, E; Biancofiore, I; Malancona, S; Graziani, R; Roberts, D; Willis, P; Bresciani, A; Gennari, N; Cecchetti, O; Monteagudo, E; Orsale, MV; Veneziano, M; Di Marco, A; Cellucci, A; Laufer, R; Altamura, S; Summa, V; Harper, S Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs. ACS Med Chem Lett 7:454-9 (2016) [PubMed]  Article
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50175039
Synonyms:
CHEMBL3808639
Type:
Small organic molecule
Emp. Form.:
C25H28N6O3S
Mol. Mass.:
492.593
SMILES:
CNC(=O)CCCCC[C@H](NC(=O)c1cncs1)c1ncc([nH]1)-c1cc2ccccc2nc1OC |r|
Structure:
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