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Target
Tyrosyl-DNA phosphodiesterase 2
Ligand
BDBM50179184
Substrate
n/a
Meas. Tech.
ChEMBL_1582563 (CHEMBL3816825)
IC50
>111000±n/a nM
Citation
 Kossmann, BR; Abdelmalak, M; Lopez, S; Tender, G; Yan, C; Pommier, Y; Marchand, C; Ivanov, I Discovery of selective inhibitors of tyrosyl-DNA phosphodiesterase 2 by targeting the enzyme DNA-binding cleft. Bioorg Med Chem Lett 26:3232-3236 (2016) [PubMed]  Article
Target
Name:
Tyrosyl-DNA phosphodiesterase 2
Synonyms:
TYDP2_MOUSE | Tdp2 | Ttrap | Tyrosyl-DNA phosphodiesterase 2 (mTDP2 WT)
Type:
Protein
Mol. Mass.:
41027.02
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
370
Sequence:
MASGSSSDAAEPAGPAGRAASAPEAAQAEEDRVKRRRLQCLGFALVGGCDPTMVPSVLRENDWQTQKALSAYFELPENDQGWPRQPPTSFKSEAYVDLTNEDANDTTILEASPSGTPLEDSSTISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPPYCAYLKKRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMMRNLLCVNVSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDSTTVIFAGDTNLRDQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNLRIPAAYKHRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLCTLNVVL
  
Inhibitor
Name:
BDBM50179184
Synonyms:
CHEMBL264425
Type:
Small organic molecule
Emp. Form.:
C20H20N2O6S2
Mol. Mass.:
448.513
SMILES:
OC(=O)C(CSSCC(NC(=O)c1ccccc1)C(O)=O)NC(=O)c1ccccc1
Structure:
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