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Target
Proteasome subunit beta type-5
Ligand
BDBM50195933
Substrate
n/a
Meas. Tech.
ChEMBL_1618119 (CHEMBL3860288)
Ki
10260±n/a nM
Citation
 Di Giovanni, C; Ettari, R; Sarno, S; Rotondo, A; Bitto, A; Squadrito, F; Altavilla, D; Schirmeister, T; Novellino, E; Grasso, S; Zappalą, M; Lavecchia, A Identification of noncovalent proteasome inhibitors with high selectivity for chymotrypsin-like activity by a multistep structure-based virtual screening. Eur J Med Chem 121:578-591 (2016) [PubMed]  Article
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50195933
Synonyms:
CHEMBL3612421
Type:
Small organic molecule
Emp. Form.:
C27H35N3O7
Mol. Mass.:
513.5827
SMILES:
COC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)OCc1ccccc1 |r|
Structure:
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