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Target
Histone deacetylase 8
Ligand
BDBM50202000
Substrate
n/a
Meas. Tech.
ChEBML_1623659
IC50
130±n/a nM
Citation
 Lee, HY; Chang, CY; Su, CJ; Huang, HL; Mehndiratta, S; Chao, YH; Hsu, CM; Kumar, S; Sung, TY; Huang, YZ; Li, YH; Yang, CR; Liou, JP 2-(Phenylsulfonyl)quinoline N-hydroxyacrylamides as potent anticancer agents inhibiting histone deacetylase. Eur J Med Chem 122:92-101 (2016) [PubMed]  Article
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50202000
Synonyms:
CHEMBL3973951
Type:
Small organic molecule
Emp. Form.:
C18H14N2O4S
Mol. Mass.:
354.38
SMILES:
ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)c1ccc2ccccc2n1
Structure:
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