Reaction Details  Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50204048
Substrate
n/a
Meas. Tech.
ChEMBL_1626008 (CHEMBL3868477)
Ki
3.5±n/a nM
Citation
 Rossi, D; Rui, M; Di Giacomo, M; Schepmann, D; Wünsch, B; Monteleone, S; Liedl, KR; Collina, S Gaining in pan-affinity towards sigma 1 and sigma 2 receptors. SAR studies on arylalkylamines. Bioorg Med Chem 25:11-19 (2017) [PubMed]  Article
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50204048
Synonyms:
CHEMBL3942914
Type:
Small organic molecule
Emp. Form.:
C23H31NO
Mol. Mass.:
337.4983
SMILES:
COc1ccc(cc1)C(C)CCN1CCC(Cc2ccccc2)CC1
Structure:
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