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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Ligand
BDBM50218249
Substrate
n/a
Meas. Tech.
ChEMBL_195885 (CHEMBL799007)
IC50
75±n/a nM
Citation
 Buckley, G; Cooper, N; Dyke, HJ; Galleway, F; Gowers, L; Gregory, JC; Hannah, DR; Haughan, AF; Hellewell, PG; Kendall, HJ; Lowe, C; Maxey, R; Montana, JG; Naylor, R; Picken, CL; Runcie, KA; Sabin, V; Tuladhar, BR; Warneck, JB 7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma. Bioorg Med Chem Lett 10:2137-40 (2000) [PubMed]
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Synonyms:
Dpde1 | PDE4C_RAT | Pde4c
Type:
PROTEIN
Mol. Mass.:
60038.21
Organism:
Rattus norvegicus
Description:
ChEMBL_104732
Residue:
536
Sequence:
NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQQAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSRSGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYLLTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPLPLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
  
Inhibitor
Name:
BDBM50218249
Synonyms:
CHEMBL304051
Type:
Small organic molecule
Emp. Form.:
C20H20Cl2N2O3
Mol. Mass.:
407.29
SMILES:
COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(CC(C)(C)C)oc12
Structure:
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