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Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM50236222
Substrate
n/a
Meas. Tech.
ChEMBL_1658849 (CHEMBL4008461)
IC50
31±n/a nM
Citation
 Travelli, C; Aprile, S; Rahimian, R; Grolla, AA; Rogati, F; Bertolotti, M; Malagnino, F; di Paola, R; Impellizzeri, D; Fusco, R; Mercalli, V; Massarotti, A; Stortini, G; Terrazzino, S; Del Grosso, E; Fakhfouri, G; Troiani, MP; Alisi, MA; Grosa, G; Sorba, G; Canonico, PL; Orsomando, G; Cuzzocrea, S; Genazzani, AA; Galli, U; Tron, GC Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity. J Med Chem 60:1768-1792 (2017) [PubMed]  Article
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT_MOUSE | NAmPRTase | Nampt | Pbef1
Type:
PROTEIN
Mol. Mass.:
55450.71
Organism:
Mus musculus
Description:
ChEMBL_108315
Residue:
491
Sequence:
MNAAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKVRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKEVYREHFQDDVFNERGWNYILEKYDGHLPIEVKAVPEGSVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGIALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTEAPLIIRPDSGNPLDTVLKVLDILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKKWSIENVSFGSGGALLQKLTRDLLNCSFKCSYVVTNGLGVNVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGHDLLHTVFKNGKVTKSYSFDEVRKNAQLNIEQDVAPH
  
Inhibitor
Name:
BDBM50236222
Synonyms:
CHEMBL4101611
Type:
Small organic molecule
Emp. Form.:
C26H28N4O
Mol. Mass.:
412.5267
SMILES:
C(CCCOc1ccccc1-c1ccccc1)CCCn1cc(nn1)-c1cccnc1
Structure:
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