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Target
Kynurenine 3-monooxygenase
Ligand
BDBM50237998
Substrate
n/a
Meas. Tech.
ChEMBL_1662734 (CHEMBL4012415)
IC50
500±n/a nM
Citation
 Liddle, J; Beaufils, B; Binnie, M; Bouillot, A; Denis, AA; Hann, MM; Haslam, CP; Holmes, DS; Hutchinson, JP; Kranz, M; McBride, A; Mirguet, O; Mole, DJ; Mowat, CG; Pal, S; Rowland, P; Trottet, L; Uings, IJ; Walker, AL; Webster, SP The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis. Bioorg Med Chem Lett 27:2023-2028 (2017) [PubMed]  Article
Target
Name:
Kynurenine 3-monooxygenase
Synonyms:
1.14.13.9 | KMO_PSEFL | Kynurenine 3-hydroxylase | Kynurenine 3-monooxygenase | PfKMO | kmo | qbsG
Type:
PROTEIN
Mol. Mass.:
50713.22
Organism:
Pseudomonas fluorescens
Description:
ChEMBL_117445
Residue:
461
Sequence:
MTATDNARQVTIIGAGLAGTLVARLLARNGWQVNLFERRPDPRIETGARGRSINLALAERGAHALRLAGLEREVLAEAVMMRGRMVHVPGTPPNLQPYGRDDSEVIWSINRDRLNRILLDGAEAAGASIHFNLGLDSVDFARQRLTLSNVSGERLEKRFHLLIGADGCNSAVRQAMASVVDLGEHLETQPHGYKELQITPEASAQFNLEPNALHIWPHGDYMCIALPNLDRSFTVTLFLHHQSPAAQPASPCFAQLVDGHAARRFFQRQFPDLSPMLDSLEQDFEHHPTGKLATLRLTTWHVGGQAVLLGDAAHPMVPFHGQGMNCALEDAVALAEHLQSAADNASALAAFTAQRQPDALAIQAMALENYVEMSSKVASPTYLLERELGQIMAQRQPTRFIPRYSMVTFSRLPYAQAMARGQIQEQLLKFAVANHSDLTSINLDAVEHEVTRCLPPLSHLC
  
Inhibitor
Name:
BDBM50237998
Synonyms:
CHEMBL1881960
Type:
Small organic molecule
Emp. Form.:
C7H3Cl2NO2
Mol. Mass.:
204.01
SMILES:
Oc1nc2cc(Cl)c(Cl)cc2o1
Structure:
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