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Target
Proteinase-activated receptor 2
Ligand
BDBM85518
Substrate
n/a
Ki
260±n/a nM
Comments
PDSP_1793
Citation
 Al-Ani, B; Saifeddine, M; Kawabata, A; Renaux, B; Mokashi, S; Hollenberg, MD Proteinase-activated receptor 2 (PAR(2)): development of a ligand-binding assay correlating with activation of PAR(2) by PAR(1)- and PAR(2)-derived peptide ligands. J Pharmacol Exp Ther 290:753-60 (1999) [PubMed]
Target
Name:
Proteinase-activated receptor 2
Synonyms:
F2rl1 | PAR2_RAT | Par2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44466.34
Organism:
RAT
Description:
PAR2 F2RL1 RAT::Q63645
Residue:
397
Sequence:
MRSLSLAWLLGGITLLAASASCNRTVNAPGPNSKGRSLIGRLDTPPPITGKGAPVEPGFSVDEFSASVLTGKLTTVFLPVIYIIVFVIGLPSNGMALWVFFFRTKKKHPAVIYMANLALADLLSVIWFPLKISYHLHGNDWTYGDALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKRANIAVGVSLAIWLLIFLVTIPLYVMRQTIYIPALNITTCHDVLPEEVLVGDMFSYFLSLAIGVFLFPALLTASAYVLMIKTLRSSAMDEHSEKKRRRAIRLIITVLSMYFICFAPSNVLLVVHYFLIKSQRQSHVYALYLVALCLSTLNSCIDPFVYYFVSKDFRDQARNALLCRSVRTVKRMQISLTSNKFSRKSSSYSSSSTSVKTSY
  
Inhibitor
Name:
BDBM85518
Synonyms:
tc-NH2 | trans-cinnamoyl-LIGRLO-NH2
Type:
Small organic molecule
Emp. Form.:
C40H67N11O7
Mol. Mass.:
814.0295
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)C=Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN)C(N)=O |r,w:16.15|
Structure:
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