Ki Summary

Reaction Details

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Target

Somatostatin receptor type 3

Ligand

BDBM85728

Substrate

n/a

1000±n/a nM

Comments

PDSP_7429

Citation

Reubi, JC; Schaer, JC; Wenger, S; Hoeger, C; Erchegyi, J; Waser, B; Rivier, J SST3-selective potent peptidic somatostatin receptor antagonists. Proc Natl Acad Sci U S A 97:13973-8 (2000) [PubMed] Article

More Info.:

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Target

Name:

Somatostatin receptor type 3

Synonyms:

SOMATOSTATIN SST3 | SS-3-R | SS3-R | SS3R | SSR-28 | SSR3_HUMAN | SSTR3 | Somatostatin receptor type 3 (SSTR3)

Type:

Protein

Mol. Mass.:

45855.97

Organism:

Homo sapiens (Human)

Description:

P32745

Residue:

418

Sequence:

MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEESREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL

Inhibitor

Name:

BDBM85728

Synonyms:

des-AA 1,2,4,5,12,13[D-2Nal8]-SS (ODN-8) | des-AA 1,2,4,5,12,13[DAgl8(2-naphthoyl)]-SS

Type:

Small organic molecule

Emp. Form.:

C56H66N10O11S2

Mol. Mass.:

1119.314

SMILES:

C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)c2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O

Structure: