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Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM82217
Substrate
n/a
Ki
2298±n/a nM
Comments
PDSP_1710
Citation
 Owens, JM; Knight, DL; Nemeroff, CB [Second generation SSRIS: human monoamine transporter binding profile of escitalopram and R-fluoxetine]. Encephale 28:350-5 (2002) [PubMed]
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT2C | HTR2C
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51631.71
Organism:
PORCINE
Description:
K7GSR7
Residue:
457
Sequence:
MVNLRKAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIILTIGGNILVIMAVSLEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISLGVSVPIPVIGLRDEDKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIHVLRRQALMLLRGHTEEPPGISLDFLKCCKRNTDEENAANPNQDLNPRRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKVYRRAFSNYLRCNYKADKKPPIRQIPRVAATALSGRELNVNIYRHTNEPVIKKADDNEPGIEMQVENLELPVNPSNVVSERISSV
  
Inhibitor
Name:
BDBM82217
Synonyms:
CHEMBL284994 | CP-52003 | SERTRALINE | [4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-methyl-amine
Type:
n/a
Emp. Form.:
C17H17Cl2N
Mol. Mass.:
306.23
SMILES:
CN[C@@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12
Structure:
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