Reaction Details  Report a problem with these data
Target
Glutathione S-transferase E2
Ligand
BDBM86111
Substrate
n/a
Meas. Tech.
GST Inhibition Assay
pH
6.5±0
Temperature
303.15±0 K
IC50
4.8e+3±n/a nM
Citation
 Muleya, V; Hayeshi, R; Ranson, H; Abegaz, B; Bezabih, MT; Robert, M; Ngadjui, BT; Ngandeu, F; Mukanganyama, S Modulation of Anopheles gambiae Epsilon glutathione transferase activity by plant natural products in vitro. J Enzyme Inhib Med Chem 23:391-9 (2008) [PubMed]  Article
Target
Name:
Glutathione S-transferase E2
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
24847.25
Organism:
Anopheles gambiae (African malaria mosquito)
Description:
Q9GPL8
Residue:
221
Sequence:
MSNLVLYTLHLSPPCRAVELTAKALGLELEQKTINLLTGDHLKPEFVKLNPQHTIPVLDDNGTIITESHAIMIYLVTKYGKDDSLYPKDPVKQARVNSALHFESGVLFARMRFNFERILFFGKSDIPEDRVEYVQKSYELLEDTLVDDFVAGPTMTIADFSCISTISSIMGVVPLEQSKHPRIYAWIDRLKQLPYYEEANGGGGTDLGKFVLAKKEENAKA
  
Inhibitor
Name:
BDBM86111
Synonyms:
GGI
Type:
Small organic molecule
Emp. Form.:
C38H50O6
Mol. Mass.:
602.8
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#6]C1([#6])[#6](-[#6]\[#6]=[#6](\[#6])-[#6])-[#6]C2([#6]\[#6]=[#6](\[#6])-[#6])[#6](=O)-[#6](-[#6](=O)-c3ccc(-[#8])c(-[#8])c3)-[#6](=O)C1([#6]\[#6]=[#6](\[#6])-[#6])[#6]2=O |TLB:43:42:23.34.21:6.14.8|
Structure:
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