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Target
Kappa-type opioid receptor
Ligand
BDBM26739
Substrate
n/a
Ki
>10000±n/a nM
Comments
PDSP_5529
Citation
 Gobbi, G; Bambico, FR; Mangieri, R; Bortolato, M; Campolongo, P; Solinas, M; Cassano, T; Morgese, MG; Debonnel, G; Duranti, A; Tontini, A; Tarzia, G; Mor, M; Trezza, V; Goldberg, SR; Cuomo, V; Piomelli, D Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis. Proc Natl Acad Sci U S A 102:18620-5 (2005) [PubMed]  Article
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM26739
Synonyms:
3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate | CHEMBL184238 | URB 597 | URB-597 | URB597 | US9187413, 1a (URB597)
Type:
Small organic molecule
Emp. Form.:
C20H22N2O3
Mol. Mass.:
338.4003
SMILES:
NC(=O)c1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1
Structure:
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