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Target
DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM87089
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
>99000±n/a nM
Comments
extracted
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID]
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
  
Inhibitor
Name:
BDBM87089
Synonyms:
MLS-0463471.0001 | N-[5-(2-methoxyethylsulfanyl)-1,3,4-thiadiazol-2-yl]-2-phenyl-butanamide | N-[5-(2-methoxyethylsulfanyl)-1,3,4-thiadiazol-2-yl]-2-phenylbutanamide | N-[5-(2-methoxyethylthio)-1,3,4-thiadiazol-2-yl]-2-phenyl-butyramide | N-[5-(2-methoxyethylthio)-1,3,4-thiadiazol-2-yl]-2-phenylbutanamide | cid_2963268
Type:
Small organic molecule
Emp. Form.:
C15H19N3O2S2
Mol. Mass.:
337.46
SMILES:
CCC(C(=O)Nc1nnc(SCCOC)s1)c1ccccc1
Structure:
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