Reaction Details 
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM87098
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
>99000±n/a nM
Comments
extracted
Citation
PubChem, PC SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID]More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM87098
Synonyms:
1-(2-besylethylthio)-4-butyl-[1,2,4]triazolo[4,3-a]quinazolin-5-one | 1-[2-(benzenesulfonyl)ethylsulfanyl]-4-butyl-[1,2,4]triazolo[4,3-a]quinazolin-5-one | 1-[2-(benzenesulfonyl)ethylthio]-4-butyl-[1,2,4]triazolo[4,3-a]quinazolin-5-one | 4-butyl-1-[2-(phenylsulfonyl)ethylsulfanyl]-[1,2,4]triazolo[4,3-a]quinazolin-5-one | MLS-0463480.0001 | cid_41907126
Type:
Small organic molecule
Emp. Form.:
C21H22N4O3S2
Mol. Mass.:
442.554
SMILES:
CCCCn1c2nnc(SCCS(=O)(=O)c3ccccc3)n2c2ccccc2c1=O
Structure:
