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Target
DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM87112
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
>99000±n/a nM
Comments
extracted
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID]
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
  
Inhibitor
Name:
BDBM87112
Synonyms:
2-[[5-(4-methoxyphenyl)-1H-1,2,4-triazol-3-yl]sulfanyl]-N-methyl-N-(thiophen-2-ylmethyl)acetamide | 2-[[5-(4-methoxyphenyl)-1H-1,2,4-triazol-3-yl]sulfanyl]-N-methyl-N-(thiophen-2-ylmethyl)ethanamide | 2-[[5-(4-methoxyphenyl)-1H-1,2,4-triazol-3-yl]thio]-N-methyl-N-(2-thenyl)acetamide | 2-[[5-(4-methoxyphenyl)-1H-1,2,4-triazol-3-yl]thio]-N-methyl-N-(thiophen-2-ylmethyl)acetamide | MLS-0463494.0001 | cid_7901408
Type:
Small organic molecule
Emp. Form.:
C17H18N4O2S2
Mol. Mass.:
374.48
SMILES:
COc1ccc(cc1)-c1nnc(SCC(=O)N(C)Cc2cccs2)[nH]1
Structure:
Search PDB for entries with ligand similarity: