Reaction Details 
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM87117
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
>99000±n/a nM
Comments
extracted
Citation
PubChem, PC SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID]More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM87117
Synonyms:
2-[(5-oxidanylidene-4-propyl-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)sulfanyl]-N-(phenylmethyl)ethanamide | 2-[(5-oxo-4-propyl-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)thio]-N-(phenylmethyl)acetamide | MLS-0463496.0001 | N-benzyl-2-[(5-keto-4-propyl-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)thio]acetamide | N-benzyl-2-[(5-oxo-4-propyl-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)sulfanyl]acetamide | cid_2493460
Type:
Small organic molecule
Emp. Form.:
C21H21N5O2S
Mol. Mass.:
407.489
SMILES:
CCCn1c2nnc(SCC(=O)NCc3ccccc3)n2c2ccccc2c1=O
Structure:
