Reaction Details 
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80360
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
12300±n/a nM
Comments
extracted
Citation
PubChem, PC SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID]More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM80360
Synonyms:
(10Z)-10-[(2-hydroxyethylamino)methylene]-8,8-dimethyl-pyrano[2,3-f]chromene-2,9-quinone | (10Z)-10-[(2-hydroxyethylamino)methylidene]-8,8-dimethyl-pyrano[2,3-f]chromene-2,9-dione | (10Z)-10-[(2-hydroxyethylamino)methylidene]-8,8-dimethylpyrano[2,3-f][1]benzopyran-2,9-dione | (10Z)-10-[(2-hydroxyethylamino)methylidene]-8,8-dimethylpyrano[2,3-f]chromene-2,9-dione | 10-[(2-Hydroxy-ethylamino)-methylene]-8,8-dimethyl-10H-pyrano[2,3-f]chromene-2,9 | MLS000043646 | SMR000082828 | cid_5771282
Type:
Small organic molecule
Emp. Form.:
C17H17NO5
Mol. Mass.:
315.3206
SMILES:
CC1(C)Oc2ccc3ccc(=O)oc3c2C(=CNCCO)C1=O |w:16.18|
Structure:
