Reaction Details  Report a problem with these data
Target
Macrophage migration inhibitory factor
Ligand
BDBM92409
Substrate
n/a
Meas. Tech.
Tautomerase Activity Assay
IC50
6.4e+3± 8e+2 nM
Citation
 Alam, A; Haldar, S; Thulasiram, HV; Kumar, R; Goyal, M; Iqbal, MS; Pal, C; Dey, S; Bindu, S; Sarkar, S; Pal, U; Maiti, NC; Bandyopadhyay, U Novel Anti-inflammatory Activity of Epoxyazadiradione against Macrophage Migration Inhibitory Factor: INHIBITION OF TAUTOMERASE AND PROINFLAMMATORY ACTIVITIES OF MACROPHAGE MIGRATION INHIBITORY FACTOR. J Biol Chem 287:24844-61 (2012) [PubMed]  Article
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM92409
Synonyms:
Epoxyazadiradione
Type:
Small organic molecule
Emp. Form.:
C28H34O6
Mol. Mass.:
466.566
SMILES:
CC(=O)O[C@@H]1C[C@H]2C(C)(C)C(=O)C=C[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](C(=O)[C@H]4O[C@@]34[C@]12C)c1ccoc1 |c:12|
Structure:
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