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Target
EEF1AKMT4-ECE2 readthrough transcript protein
Ligand
BDBM92502
Substrate
n/a
Meas. Tech.
Enzymatic Assay
Ki
22.3±0.3 nM
IC50
43.4±0.5 nM
Citation
 Ouimet, T; Orng, SV; Poras, H; Gagnidze, K; Devi, LA; Fournié-Zaluski, MC; Roques, BP Identification of an endothelin-converting enzyme-2-specific fluorigenic substrate and development of an in vitro and ex vivo enzymatic assay. J Biol Chem 285:34390-400 (2010) [PubMed]  Article
Target
Name:
EEF1AKMT4-ECE2 readthrough transcript protein
Synonyms:
EEF1AKMT4-ECE2 | EFCE2_HUMAN | Endothelin-converting enzyme 2 | Endothelin-converting enzyme 2 (ECE-2) | Endothelin-converting enzyme 2 (ECE2) | Endothelin-converting enzyme 2 region
Type:
Enzyme
Mol. Mass.:
99745.05
Organism:
Homo sapiens (Human)
Description:
P0DPD8
Residue:
883
Sequence:
MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPEDRILVLGCGNSALSYELFLGGFPNVTSVDYSSVVVAAMQARHAHVPQLRWETMDVRKLDFPSASFDVVLEKGTLDALLAGERDPWTVSSEGVHTVDQVLSEVGFQKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW
  
Inhibitor
Name:
BDBM92502
Synonyms:
(2S)-2-[2-(5-bromo-2,3-dihydro-1H-inden-1-yl)-3-sulfanylpropanamido]-3-(1H-indol-3-yl)propanoic acid, 1
Type:
Organic molecule
Emp. Form.:
C23H23BrN2O3S
Mol. Mass.:
487.409
SMILES:
OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(CS)C1CCc2cc(Br)ccc12 |r|
Structure:
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