Reaction Details  Report a problem with these data
Target
Genome polyprotein
Ligand
BDBM92898
Substrate
n/a
Meas. Tech.
Competitive Inhibition Assay
Ki
15±1.5 nM
Citation
 Dahl, G; Arenas, OG; Danielson, UH Hepatitis C virus NS3 protease is activated by low concentrations of protease inhibitors. Biochemistry 48:11592-602 (2009) [PubMed]  Article
Target
Name:
Genome polyprotein
Synonyms:
NS3 protein
Type:
Protein
Mol. Mass.:
45665.89
Organism:
Hepatitis C virus
Description:
Q04045
Residue:
428
Sequence:
VFTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLVVLATATPPGSVTVSHPNIEEVALSTTGEIPFYGKAIPLEVIKGGRHLIFCHSKKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVSTDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEVT
  
Inhibitor
Name:
BDBM92898
Synonyms:
NS3 Protease Inhibitor, 9
Type:
Small molecule
Emp. Form.:
C37H44N4O8
Mol. Mass.:
672.7673
SMILES:
COc1ccc2c(O[C@@H]3C[C@H](N(C3)C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)C(=O)N[C@@]3(CC3C=C)C(O)=O)cc(nc2c1)-c1ccccc1 |r|
Structure:
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