Reaction Details  Report a problem with these data
Target
Peptidyl-prolyl cis-trans isomerase A
Ligand
BDBM92916
Substrate
n/a
Meas. Tech.
PPIase Assay
pH
7.8±n/a
Temperature
278.15±n/a K
Ki
1.0e+4± 2e+3 nM
Comments
extracted
Citation
 Daum, S; Schumann, M; Mathea, S; Aumüller, T; Balsley, MA; Constant, SL; de Lacroix, BF; Kruska, F; Braun, M; Schiene-Fischer, C Isoform-specific inhibition of cyclophilins. Biochemistry 48:6268-77 (2009) [PubMed]  Article
Target
Name:
Peptidyl-prolyl cis-trans isomerase A
Synonyms:
CYPA | CYPA PPIase | Cyclophilin A | Cyclosporin A-binding protein | PPIA | PPIA_HUMAN | PPIase A | Peptidyl-prolyl cis-trans isomerase A | Rotamase A
Type:
Protein
Mol. Mass.:
18015.32
Organism:
Homo sapiens (Human)
Description:
P62937
Residue:
165
Sequence:
MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
  
Inhibitor
Name:
BDBM92916
Synonyms:
Aryl 1-indanylketone, 5
Type:
Small molecule
Emp. Form.:
C18H15F3O2
Mol. Mass.:
320.3057
SMILES:
COc1ccc(cc1C(=O)C1CCc2ccccc12)C(F)(F)F
Structure:
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