Reaction Details Report a problem with these data
Target
DNA ligase A
Ligand
BDBM93107
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
4.60e+4± 2.5e+3 nM
Citation
Dube, C; Kukshal, V; Srivastava, SK; Tripathi, RP; Ramachandran, R NAD+-dependent DNA ligase (Rv3014c) from M. tuberculosis: Strategies for inhibitor design Medicinal Chemistry Research 17:189-198 (2008)
More Info.:
Target
Name:
DNA ligase A
Synonyms:
DNA Ligase (MtuLigA) | DNLJ_MYCTU | NAD-dependent DNA ligase | Polydeoxyribonucleotide synthase [NAD(+)] | Polydeoxyribonucleotide synthase [NAD+] | lig | ligA
Type:
Enzyme
Mol. Mass.:
75276.13
Organism:
Mycobacterium tuberculosis
Description:
The C-terminally His-tagged full-length MtuLigA protein was cloned and expressed in E. coli.
Residue:
691
Sequence:
MSSPDADQTAPEVLRQWQALAEEVREHQFRYYVRDAPIISDAEFDELLRRLEALEEQHPELRTPDSPTQLVGGAGFATDFEPVDHLERMLSLDNAFTADELAAWAGRIHAEVGDAAHYLCELKIDGVALSLVYREGRLTRASTRGDGRTGEDVTLNARTIADVPERLTPGDDYPVPEVLEVRGEVFFRLDDFQALNASLVEEGKAPFANPRNSAAGSLRQKDPAVTARRRLRMICHGLGHVEGFRPATLHQAYLALRAWGLPVSEHTTLATDLAGVRERIDYWGEHRHEVDHEIDGVVVKVDEVALQRRLGSTSRAPRWAIAYKYPPEEAQTKLLDIRVNVGRTGRITPFAFMTPVKVAGSTVGQATLHNASEIKRKGVLIGDTVVIRKAGDVIPEVLGPVVELRDGSEREFIMPTTCPECGSPLAPEKEGDADIRCPNARGCPGQLRERVFHVASRNGLDIEVLGYEAGVALLQAKVIADEGELFALTERDLLRTDLFRTKAGELSANGKRLLVNLDKAKAAPLWRVLVALSIRHVGPTAARALATEFGSLDAIAAASTDQLAAVEGVGPTIAAAVTEWFAVDWHREIVDKWRAAGVRMVDERDESVPRTLAGLTIVVTGSLTGFSRDDAKEAIVARGGKAAGSVSKKTNYVVAGDSPGSKYDKAVELGVPILDEDGFRRLLADGPASRT