Reaction Details  Report a problem with these data
Target
Cysteine proteinase falcipain 3
Ligand
BDBM93124
Substrate
n/a
Meas. Tech.
In Vitro Inhibition Assay
IC50
2.94e+4±n/a nM
Citation
 Goud, PM; Sheri, A; Desai, PV; Watkins, EB; Tekwani, B; Sabnis, Y; Gut, J; Rosenthal, PJ; Avery, MA Design, synthesis and evaluation of trisubstituted thiazoles targeting plasmodium falciparum cysteine proteases Medicinal Chemistry Research 14:74-105 (2005)  
Target
Name:
Cysteine proteinase falcipain 3
Synonyms:
Cysteine protease falcipain-3
Type:
Protein
Mol. Mass.:
56666.98
Organism:
Plasmodium falciparum
Description:
Q9NAW4
Residue:
492
Sequence:
MEYHMEYSPNEVIKQEREVFVGKEKSGSKFKRKRSIFIVLTVSICFMFALMLFYFTRNENNKTLFTNSLSNNINDDYIINSLLKSESGKKFIVSKLEELISSYDKEKKMRTTGAEENNMNMNGIDDKDNKSVSFVNKKNGNLKVNNNNQVSYSNLFDTKFLMDNLETVNLFYIFLKENNKKYETSEEMQKRFIIFSENYRKIELHNKKTNSLYKRGMNKFGDLSPEEFRSKYLNLKTHGPFKTLSPPVSYEANYEDVIKKYKPADAKLDRIAYDWRLHGGVTPVKDQALCGSCWAFSSVGSVESQYAIRKKALFLFSEQELVDCSVKNNGCYGGYITNAFDDMIDLGGLCSQDDYPYVSNLPETCNLKRCNERYTIKSYVSIPDDKFKEALRYLGPISISIAASDDFAFYRGGFYDGECGAAPNHAVILVGYGMKDIYNEDTGRMEKFYYYIIKNSWGSDWGEGGYINLETDENGYKKTCSIGTEAYVPLLE
  
Inhibitor
Name:
BDBM93124
Synonyms:
Trisubsituted thiazole, 14
Type:
Small molecule
Emp. Form.:
C27H31NO2S2
Mol. Mass.:
465.671
SMILES:
OCCCc1sc(C=CC(=O)CSCCCc2ccccc2)nc1CCc1ccccc1 |w:7.6|
Structure:
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