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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM4099
Substrate
Gastrin-based substrate
Meas. Tech.
Src Inhibition Assay
IC50
500±n/a nM
Citation
 Dow, RL; Chou, TT; Bechle, BM; Goddard, C; Larson, ER Identification of tricyclic analogs related to ellagic acid as potent/selective tyrosine protein kinase inhibitors. J Med Chem 37:2224-31 (1994) [PubMed]  Article
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM4099
Synonyms:
9-(3-phenylpropyl)-9H-carbazole-1,2,6,7-tetrol | Carbazole deriv. 9i
Type:
Small organic molecule
Emp. Form.:
C21H19NO4
Mol. Mass.:
349.3799
SMILES:
Oc1ccc2c3cc(O)c(O)cc3n(CCCc3ccccc3)c2c1O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Gastrin-based substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
2351.54
Organism:
n/a
Description:
50 uM ATP as co-substrate.
Residue:
19
Sequence:
KKKGPWLEEEEEAYGWLDF