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Target
Epidermal growth factor receptor [696-1210,T790M]
Ligand
BDBM102620
Substrate
n/a
IC50
4280±0.0 nM
Citation
 Liu, F; Zhang, X; Weisberg, E; Chen, S; Hur, W; Wu, H; Zhao, Z; Wang, W; Mao, M; Cai, C; Simon, NI; Sanda, T; Wang, J; Look, AT; Griffin, JD; Balk, SP; Liu, Q; Gray, NS Discovery of a Selective Irreversible BMX Inhibitor for Prostate Cancer. ACS Chem Biol 8:1423-8 (2013) [PubMed]  Article
Target
Name:
Epidermal growth factor receptor [696-1210,T790M]
Synonyms:
EGF-R Tyrosine Kinase Mutant (T790M) | EGFR | EGFR_HUMAN | ERBB | ERBB1 | HER1 | Receptor tyrosine-protein kinase ErbB-1
Type:
Cytoplasmic region
Mol. Mass.:
57805.41
Organism:
Homo sapiens (Human)
Description:
EGFR-T790M was purchased from Upstate.
Residue:
515
Sequence:
GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA
  
Inhibitor
Name:
BDBM102620
Synonyms:
BMX-IN-1 | N-[5-[9-[4-(methanesulfonamido)phenyl]-2-oxobenzo[h][1, | US10000483, Compound I-14
Type:
Small organic molecule
Emp. Form.:
C29H24N4O4S
Mol. Mass.:
524.59
SMILES:
Cc1ccc(cc1NC(=O)C=C)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1ccc(NS(C)(=O)=O)cc1
Structure:
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