Reaction Details 
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Mitogen-activated protein kinase 1
Ligand
BDBM103302
Substrate
n/a
Meas. Tech.
IMAP Assay
IC50
0.8±0.0 nM
Citation
Cooper, AB; Deng, Y; Shipps, Jr., GW; Shih, N; Zhu, HY; Sun, R; Kelly, JM; Doll, RJ; Nan, Y; Wang, T; Desai, JA; Wang, JJ; Dong, Y; Madison, VS; Xiao, L; Hruza, AW; Siddiqui, MA; Samatar, AA; Paliwal, S; Tsui, H; Celebi, AA; Wu, Y; Boga, SB; Alhassan, A; Gao, X; Zhu, L; Patel, M Compounds that are ERK inhibitors US Patent US8546404 Publication Date 10/1/2013More Info.:
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERT1 | Erk2 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK2) | MAP kinase 1 | MAP kinase 2 | MAP kinase ERK2 | MAPK 1 | MAPK 2 | MK01_MOUSE | Mapk | Mapk1 | Mitogen-activated protein kinase 2 | Prkm1 | p42 | p42-MAPK
Type:
Protein
Mol. Mass.:
41278.65
Organism:
Mus musculus (Mouse)
Description:
P63085
Residue:
358
Sequence:
MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
Inhibitor
Name:
BDBM103302
Synonyms:
SCH772984 | US8546404, 6
Type:
Small organic molecule
Emp. Form.:
C33H33N9O2
Mol. Mass.:
587.6742
SMILES:
O=C(CN1CC[C@@H](C1)C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)N1CCN(CC1)c1ccc(cc1)-c1ncccn1 |r|
Structure:
