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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50340728
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
222±0.0 nM
IC50
477±0.0 nM
Citation
 Ivashchenko, AA; Ivashchenko, AV; Savchuk, NF (EN) 3-sulfonyl-pyrazolo[1,5-a] pyrimidines / antagonists of serotonin 5-HT6 receptors, methods for the production and the use thereof US Patent  US8552005 Publication Date 10/8/2013
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50340728
Synonyms:
2-{[5,7-Dimethyl-3-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidin-2-yl]oxy}ethanol | CHEMBL1762571 | US8552005, 1.1(2)
Type:
Small organic molecule
Emp. Form.:
C16H17N3O4S
Mol. Mass.:
347.389
SMILES:
Cc1cc(C)n2nc(OCCO)c(c2n1)S(=O)(=O)c1ccccc1
Structure:
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