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Target
Carboxypeptidase B2
Ligand
BDBM109240
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
14±n/a nM
Citation
 Nagata, T; Inoue, M; Ashida, Y; Noguchi, K; Ono, M Cycloalkyl-substituted imidazole derivative US Patent  US8609710 Publication Date 12/17/2013
Target
Name:
Carboxypeptidase B2
Synonyms:
CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:
Enzyme
Mol. Mass.:
48432.74
Organism:
Homo sapiens (Human)
Description:
Q96IY4
Residue:
423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV
  
Inhibitor
Name:
BDBM109240
Synonyms:
US8609710, 4
Type:
Small organic molecule
Emp. Form.:
C15H25N3O2
Mol. Mass.:
279.3779
SMILES:
CCC1CC(C1)n1cnc(CC(CCCN)C(O)=O)c1 |(-4.82,4.9,;-3.34,4.5,;-2.94,3.02,;-1.6,2.25,;-2.37,.91,;-3.71,1.68,;-1.98,-.58,;-2.88,-1.82,;-1.98,-3.07,;-.51,-2.59,;.82,-3.36,;2.16,-2.59,;2.16,-1.05,;3.49,-.28,;3.49,1.26,;4.82,2.03,;3.49,-3.36,;3.49,-4.9,;4.82,-2.59,;-.51,-1.05,)|
Structure:
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