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Target
Carboxypeptidase B2
Ligand
BDBM109241
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
35±n/a nM
Citation
 Nagata, T; Inoue, M; Ashida, Y; Noguchi, K; Ono, M Cycloalkyl-substituted imidazole derivative US Patent  US8609710 Publication Date 12/17/2013
Target
Name:
Carboxypeptidase B2
Synonyms:
CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:
Enzyme
Mol. Mass.:
48432.74
Organism:
Homo sapiens (Human)
Description:
Q96IY4
Residue:
423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV
  
Inhibitor
Name:
BDBM109241
Synonyms:
US8609710, 5
Type:
Small organic molecule
Emp. Form.:
C14H23N3O2
Mol. Mass.:
265.3513
SMILES:
CC1CC(C1)n1cnc(CC(CCCN)C(O)=O)c1 |(-3.89,4.7,;-3.5,3.21,;-2.16,2.44,;-2.93,1.11,;-4.27,1.88,;-2.53,-.38,;-3.44,-1.62,;-2.53,-2.87,;-1.07,-2.39,;.26,-3.16,;1.6,-2.39,;1.6,-.85,;2.93,-.08,;2.93,1.46,;4.27,2.23,;2.93,-3.16,;2.93,-4.7,;4.27,-2.39,;-1.07,-.85,)|
Structure:
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