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Target
Carboxypeptidase B2
Ligand
BDBM109249
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
12±n/a nM
Citation
 Nagata, T; Inoue, M; Ashida, Y; Noguchi, K; Ono, M Cycloalkyl-substituted imidazole derivative US Patent  US8609710 Publication Date 12/17/2013
Target
Name:
Carboxypeptidase B2
Synonyms:
CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:
Enzyme
Mol. Mass.:
48432.74
Organism:
Homo sapiens (Human)
Description:
Q96IY4
Residue:
423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV
  
Inhibitor
Name:
BDBM109249
Synonyms:
US8609710, 13
Type:
Small organic molecule
Emp. Form.:
C19H29N3O2
Mol. Mass.:
331.4525
SMILES:
NCCCC(Cc1cn(cn1)C1C2CC3CC(C2)CC1C3)C(O)=O |TLB:8:11:13:15.16.17,THB:15:14:11:18.16.17,15:16:11:13.14.20,18:19:13:15.16.17,18:16:13:11.20.19,(5.01,2.01,;3.68,1.24,;3.68,-.3,;2.34,-1.07,;2.34,-2.61,;1.01,-3.38,;-.32,-2.61,;-.32,-1.07,;-1.79,-.6,;-2.69,-1.84,;-1.79,-3.09,;-2.56,.74,;-4.05,.92,;-5.01,2.01,;-4.19,3.43,;-4.58,4.92,;-3.47,3.62,;-4.24,2.29,;-1.93,3.62,;-1.93,2.08,;-2.86,3.27,;3.68,-3.38,;3.68,-4.92,;5.01,-2.61,)|
Structure:
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