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Target
Carboxypeptidase B2
Ligand
BDBM109250
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
13±n/a nM
Citation
 Nagata, T; Inoue, M; Ashida, Y; Noguchi, K; Ono, M Cycloalkyl-substituted imidazole derivative US Patent  US8609710 Publication Date 12/17/2013
Target
Name:
Carboxypeptidase B2
Synonyms:
CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:
Enzyme
Mol. Mass.:
48432.74
Organism:
Homo sapiens (Human)
Description:
Q96IY4
Residue:
423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV
  
Inhibitor
Name:
BDBM109250
Synonyms:
US8609710, 14
Type:
Small organic molecule
Emp. Form.:
C21H29N3O3
Mol. Mass.:
371.4733
SMILES:
NCCCC(Cc1cn(cn1)[C@H]1CC[C@@H](CC1)Oc1ccccc1)C(O)=O |r,wU:11.11,wD:14.18,(6.03,-.04,;4.7,-.81,;4.7,-2.35,;3.36,-3.12,;3.36,-4.66,;2.03,-5.43,;.69,-4.66,;.69,-3.12,;-.77,-2.64,;-1.67,-3.89,;-.77,-5.14,;-1.17,-1.16,;-2.66,-.76,;-3.05,.73,;-1.97,1.82,;-.48,1.42,;-.08,-.07,;-2.36,3.31,;-3.45,4.39,;-3.05,5.88,;-4.14,6.97,;-5.63,6.57,;-6.03,5.08,;-4.94,4,;4.7,-5.43,;4.7,-6.97,;6.03,-4.66,)|
Structure:
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