Reaction Details  Report a problem with these data
Target
Carboxypeptidase B2
Ligand
BDBM109262
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
9.8±n/a nM
Citation
 Nagata, T; Inoue, M; Ashida, Y; Noguchi, K; Ono, M Cycloalkyl-substituted imidazole derivative US Patent  US8609710 Publication Date 12/17/2013
Target
Name:
Carboxypeptidase B2
Synonyms:
CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:
Enzyme
Mol. Mass.:
48432.74
Organism:
Homo sapiens (Human)
Description:
Q96IY4
Residue:
423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV
  
Inhibitor
Name:
BDBM109262
Synonyms:
US8609710, 38
Type:
Small organic molecule
Emp. Form.:
C20H28N4O3
Mol. Mass.:
372.4613
SMILES:
NCCCC(Cc1cn(cn1)[C@H]1CC[C@@H](CC1)Oc1ccncc1)C(O)=O |r,wU:11.11,wD:14.18,(5.63,1.13,;4.3,.36,;4.3,-1.18,;2.96,-1.95,;2.96,-3.49,;1.63,-4.26,;.29,-3.49,;.29,-1.95,;-1.17,-1.48,;-2.08,-2.72,;-1.17,-3.97,;-1.57,.01,;-3.06,.41,;-3.46,1.89,;-2.37,2.98,;-.88,2.58,;-.48,1.1,;-2.76,4.47,;-4.3,4.47,;-5.07,5.8,;-6.61,5.8,;-7.38,4.47,;-6.61,3.14,;-5.07,3.14,;4.3,-4.26,;4.3,-5.8,;5.63,-3.49,)|
Structure:
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