Reaction Details  Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM113765
Substrate
n/a
Meas. Tech.
CB1 & 2 Binding Assays
pH
7.4±n/a
Temperature
303.15±n/a K
Ki
8.64e+3± 2.12e+3 nM
Comments
extracted
Citation
 Chicca, A; Caprioglio, D; Minassi, A; Petrucci, V; Appendino, G; Taglialatela-Scafati, O; Gertsch, J Functionalization of ß-Caryophyllene Generates Novel Polypharmacology in the Endocannabinoid System. ACS Chem Biol 9:1499-507 (2014) [PubMed]  Article
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM113765
Synonyms:
(E)-N-Allyl-6-((1R,2R)-3,3-dimethyl-2-(3-methylbut-3-enyl)cyclobutyl)hepta-2,6-dienamide (11b)
Type:
Small organic molecule
Emp. Form.:
C21H33NO
Mol. Mass.:
315.4928
SMILES:
CC(=C)CC[C@@H]1[C@@H](CC1(C)C)C(=C)CC\C=C\C(=O)NCC=C
Structure:
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