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Target
Group 3 secretory phospholipase A2
Ligand
BDBM78806
Substrate
n/a
Meas. Tech.
QFRET-based biochemical high throughput dose response assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2)
IC50
121855±n/a nM
Citation
 PubChem, PC QFRET-based biochemical high throughput dose response assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2) PubChem Bioassay (2014)[AID]
Target
Name:
Group 3 secretory phospholipase A2
Synonyms:
3.1.1.4 | GIII sPLA2 | Group III secretory phopholipase A2 | Group III secretory phospholipase A2 | PA2G3_HUMAN | PLA2G3 | Phosphatidylcholine 2-acylhydrolase 3 | phospholipase A2, group III | sPLA2-III
Type:
PROTEIN
Mol. Mass.:
57196.58
Organism:
Homo sapiens
Description:
ChEMBL_119722
Residue:
509
Sequence:
MGVQAGLFGMLGFLGVALGGSPALRWYRTSCHLTKAVPGNPLGYLSFLAKDAQGLALIHARWDAHRRLQSCSWEDEPELTAAYGALCAHETAWGSFIHTPGPELQRALATLQSQWEACRALEESPAGARKKRAAGQSGVPGGGHQREKRGWTMPGTLWCGVGDSAGNSSELGVFQGPDLCCREHDRCPQNISPLQYNYGIRNYRFHTISHCDCDTRFQQCLQNQHDSISDIVGVAFFNVLEIPCFVLEEQEACVAWYWWGGCRMYGTVPLARLQPRTFYNASWSSRATSPTPSSRSPAPPKPRQKQHLRKGPPHQKGSKRPSKANTTALQDPMVSPRLDVAPTGLQGPQGGLKPQGARWVCRSFRRHLDQCEHQIGPREIEFQLLNSAQEPLFHCNCTRRLARFLRLHSPPEVTNMLWELLGTTCFKLAPPLDCVEGKNCSRDPRAIRVSARHLRRLQQRRHQLQDKGTDERQPWPSEPLRGPMSFYNQCLQLTQAARRPDRQQKSWSQ
  
Inhibitor
Name:
BDBM78806
Synonyms:
1-[[1-(6-methyl-2-pyridyl)imidazole-4-carbonyl]amino]-3-phenyl-thiourea | 1-[[1-(6-methylpyridin-2-yl)imidazol-4-yl]carbonylamino]-3-phenyl-thiourea | 1-[[1-(6-methylpyridin-2-yl)imidazole-4-carbonyl]amino]-3-phenylthiourea | 1-[[[1-(6-methyl-2-pyridinyl)-4-imidazolyl]-oxomethyl]amino]-3-phenylthiourea | 2-{[1-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]carbonyl}-N-phenyl-1-hydrazinecarbothioamide | MLS000721184 | SMR000335616 | cid_1485012
Type:
Small organic molecule
Emp. Form.:
C17H16N6OS
Mol. Mass.:
352.414
SMILES:
Cc1cccc(n1)-n1cnc(c1)C(=O)NNC(=S)Nc1ccccc1
Structure:
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