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Target
Fibrinogen beta chain [164-491]
Ligand
BDBM114667
Substrate
n/a
Meas. Tech.
Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn7) to the fibrin proteolytic product D-Dimer
IC50
9247±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn7) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )] PubChem Bioassay (2013)[AID]
Target
Name:
Fibrinogen beta chain [164-491]
Synonyms:
Chain E, Fragment Double-D From Human Fibrin | FGB | FIBB_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37647.12
Organism:
Homo sapiens (Human)
Description:
gi_28373962
Residue:
328
Sequence:
DNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ
  
Inhibitor
Name:
BDBM114667
Synonyms:
5-keto-1H-benzo[cd]indole-2-carboxylic acid ethyl ester | 5-oxo-1H-benzo[cd]indole-2-carboxylic acid ethyl ester | MLS003170860 | SMR001874777 | cid_5384472 | ethyl 5-oxidanylidene-1H-benzo[cd]indole-2-carboxylate | ethyl 5-oxo-1H-benzo[cd]indole-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C14H11NO3
Mol. Mass.:
241.242
SMILES:
CCOC(=O)c1[nH]c2cccc3C(=O)C=Cc1c23 |c:14|
Structure:
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