Reaction Details  Report a problem with these data
Target
Oxysterols receptor LXR-beta
Ligand
BDBM48254
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response assay to identify agonists of the Liver-X-Receptor (LXR).
EC50
67535±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response assay to identify agonists of the Liver-X-Receptor (LXR). PubChem Bioassay (2013)[AID]
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM48254
Synonyms:
2-(4-methylphenyl)-N-(pyridin-4-ylmethylideneamino)-4-quinazolinamine | 2-(4-methylphenyl)-N-(pyridin-4-ylmethylideneamino)quinazolin-4-amine | MLS000532966 | SMR000140404 | [2-(p-tolyl)quinazolin-4-yl]-(4-pyridylmethyleneamino)amine | [2-(p-tolyl)quinazolin-4-yl]-[(E)-4-pyridylmethyleneamino]amine | cid_2846763 | isonicotinaldehyde [2-(4-methylphenyl)-4-quinazolinyl]hydrazone
Type:
Small organic molecule
Emp. Form.:
C21H17N5
Mol. Mass.:
339.3932
SMILES:
Cc1ccc(cc1)-c1nc(N=NCc2ccncc2)c2ccccc2n1 |w:10.10|
Structure:
Search PDB for entries with ligand similarity: